Police discovered the unidentified victim just after 10:30 p.m. near East 140th Street and Bruckner Boulevard.
The victim was found with head and body trauma, lying unconscious on the westbound lane of the Bruckner Expressway.
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He was pronounced dead on the scene.
A preliminary investigation has determined that the man's injuries were consistent with having been struck by a vehicle, which did not remain at the scene.
The NYPD's Highway Collision Investigation Squad is investigating.
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