As of Tuesday, there have been more than 79,000 coronavirus fatalities, topping the previous record set in December by more than a thousand, according to data from Johns Hopkins University.
The grim milestone underpins the growing demand from state officials for more vaccines so that Americans can be inoculated more quickly.
On Tuesday, President Joe Biden's COVID-19 coordinator Jeff Zients told governors that allocations would increase by around 16% starting next week, according to a source with knowledge of the call.
Biden has pushed for 100 million vaccination shots in the first 100 days of his presidency, but with a long road ahead for vaccinations, he also called for 100 days of mask-wearing.
"The brutal truth is it's going to take months before we can get the majority of Americans vaccinated. Months. In the next few months, masks, not vaccines, are the best defense against COVID-19," Biden said while announcing the federal government would buy and distribute more vaccine doses from Moderna and Pfizer.
With those additional doses, Biden said there would be enough to fully vaccinate 300 million Americans -- nearly the entire US population -- by the end of summer or early fall.
Supply of vaccines not meeting demand
Struggling after the stress of nearly a year of responding to the pandemic, states are eager to administer vaccines quickly and attempt a return to life as normal.
"We have to defeat it because Mississippians are done. We're done burying loved ones who were lost to this virus. We're done with stressed hospitals. We're done with the fearful talk of lockdowns and shutdowns. We're ready for community again," said Mississippi Gov. Tate Reeves, who announced that the state celebrated about 200,000 vaccines delivered.
The director of the Maine Center for Disease Control and Prevention said he was "very encouraged" by the new presidential administration's approach to vaccinations, but that the state is still struggling with the dearth of vaccines.
"We know that right now the number of individuals who want to be vaccinated greatly outstrips the supply of vaccine that we have available," Dr. Nirav Shah said.
Colorado Gov. Jared Polis said his conversations with the Biden administration have made him feel hopeful about the future of vaccine distribution, but that "we cannot yet count on additional supply yet."
Even if the administration delivers on the 16% increase in allocations promised, New York Gov. Andrew Cuomo told MSNBC's Nicolle Wallace that it won't be enough.
"We're functionally out. We start to get a new allocation over the next few days," Cuomo said.
Variants stoke demand and fears
Adding to public fears is the spread of variants of the coronavirus.
On Tuesday, Kentucky Gov. Andy Beshear announced that two cases of the variant first identified in the United Kingdom have been confirmed in the state.
The variant has been shown to spread especially quickly, according to CDC modeling. And a UK report released Friday states there is "a realistic possibility" that the new variant has a higher death rate than other variants.
The threat of variants has made reopening the state a greater concern in California, a recent epicenter of the pandemic in the US, Los Angeles County public health director Barbara Ferrer said.
"This would not be the time to think just because we are reopening that things are looking rosy," she said noting that asymptomatic spread is a problem. "We do need to move through the next few weeks with caution. At many other points where we've been reopening our sectors, we in fact have seen a bump up in our cases we can't really afford that."
For his part, Pfizer CEO Albert Bourla tried to calm fears around the variants with assurances that the groundwork is already being laid to fight them.
"We should not be frightened, but I think we need to be prepared," Bourla said during the Bloomberg The Year Ahead event Tuesday. "Once we discover something that it is not as effective, we will very, very quickly produce a booster dose that will be a small variation to the current one."
School reopening safety
Meanwhile, there was a glimmer of good news Tuesday for parents who are hoping to return their kids to school.
A report from the CDC said that with the right mitigation strategies, it's possible to open K-12 schools for in-person learning with minimal COVID-19 transmission.
Those mitigation strategies include wearing masks, social distancing and limiting time in shared outdoor spaces, according to the study from the CDC's Morbidity and Mortality Weekly Report.
In Ohio, Gov. Mike DeWine said he aims to have anyone who works in a school receive their first vaccine dose in the month of February at the very least in hopes of sending all students back to school by March 1.
Currently, people older than 75 and those with certain medical conditions are able to receive vaccines. On February 1, those 70 and older and employees of K-12 schools will be eligible for the vaccine, he said during a news conference Tuesday.
Schools reopening have been a priority for many officials as students across the country have spent months learning remotely. But local leaders have approached the return in various ways.
Of the 20 largest school districts in the country, nine are currently all online, eight offer a choice of either full in-person or all online, two have a hybrid plan and one in Hawaii varies plans based on infection rates among different islands.
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