The blaze broke out in a laundromat on Yonkers Avenue just after 6:30 a.m. and quickly spread to a supermarket, a dry cleaner and an insurance business, among others.
Firefighters arrived to find flames shooting through the roof, and a rear wall later collapsed.
"Our first arriving units found the structure heavily involved in fire," Yonkers Deputy Fire Chief Christopher Desantis said. "The structure suffered a collapse in the back of the rear wall, roof is heavily burnet through and compromised."
Video from Citizen App showed heavy smoke come from the businesses.
Fire officials say there were 15 people on site at the time, but none of them was hurt. One firefighter sustained a minor injury.
Yonkers Avenue was shut down in both directions as crews worked to control the fire.
Investigators are working to determine what caused the fire.
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