The 42-year-old victim was found at 63rd Drive and Booth Street in Rego Park.
The man, possibly intoxicated, was walking down the sidewalk just before 2 a.m. when witnesses heard a thud, turned around, and saw him laying in the street, investigators said.
He is believed to have been struck by a white four door sedan, which then went in reverse down Booth Street and fled the scene.
The victim, who suffered severe head trauma, was pronounced dead at North Shore Forest Hills Hospital.
The posted speed limit in the area is 25 miles per hour, but neighbors say drivers often exceed that.
Police are reviewing surveillance video in the area to look for more information.