It happened at about 3:30 a.m. Saturday on the southbound Q train platform inside the Union Square station.
According to the NYPD, the suspects walked up to a 41-year-old man and punched him in the head, causing him to fall to the platform floor.
Upon falling, his head was struck by an inbound Q train.
The victim, Francis Christie, said he had just left a Christmas party and was heading home.
"I think some altercation came up," Christie told Eyewitness News.
He said he woke up in the hospital, not remembering anything about the attack.
He is now being treated for serious injuries to his head and face.
"I've got some brain trauma and I have a bunch of staples in my head and my nose is just bleeding profusely," said Christie. "And I have some fractures around my eyes.."
Police have released surveillance video of the two men they're looking for. The NYPD describes them as an Asian man and a Hispanic man.
Anyone with information in regards to this incident is asked to call the NYPD's Crime Stoppers Hotline at 1-800-577-TIPS (8477) or for Spanish, 1-888-57-PISTA (74782).
* More Manhattan news
* Send us a news tip
* Download the abc7NY app for breaking news alerts