The fire broke out at a two and a half story row house on West 26th Street just after 6 a.m.
The fire was contained mainly to the top floor.
Firefighters were forced out of the burning building when flames shot through the roof.
No injuries were reported, but the fire has caused damage to the house next door.
West 26th Street was shut down between Avenue A and Kennedy Boulevard as firefighters continued to battle the blaze.
Raw video of the fire from NewsCopter 7:
A family of five was left homeless by the flames.