Police say Arlo Logue, also known as Jade, was last seen in Brooklyn on Monday near her home in Clinton Hill.
The 16-year-old is transgender and identifies as female.
The National Center for Missing and Exploited Children has released this poster for Arlo:
On Tuesday, the actor took to Twitter to say that Jade had gone missing and never came home after meeting up with a friend at the Barclays Center.
The tweet has since been deleted.