But is that as far as her history-making journey will take her?
Standing in her way is the man who a year ago was often dismissed as a flash in the political pan but is now the Republican presidential nominee, Donald Trump.
The stage is set for two New Yorkers to battle for the nation's highest office.
This week we discuss the presidential race with the second-longest serving member of Congress, Charles Rangel of New York, now in the last months of a 46-year stint.
I talked to him at last week's Democratic National Convention and asked him if he had ever seen as nasty and vitriolic a primary campaign and nominating conventions as these.
Also with us is Ed Cox, Chairman of the New York Republican Party.
And with a little more three months until Election Day, we'll be joined by political analyst Hank Sheinkopf.