Porzingis was 0-for-11 from the field, scoring one point on a free throw in 23 minutes of action.
Porzingis made light of his off night in talking to the media after the game Thursday.
"Kobe (Bryant) says you miss 100 percent of the shots you don't take; today I missed all hundred," he said.
Porzingis originally twisted his left knee in the first half of last Thursday's win over the Brooklyn Nets. He continued to play before exiting the game early in the third quarter.
In the ensuing days, Porzingis continued to feel soreness in his knee while working out. That discomfort is now gone and Hornacek said that Porzingis will play Thursday with no limitations.
The 22-year-old missed games against Oklahoma City on Saturday and Charlotte on Tuesday.
Porzingis has been off to a strong start in his third season, averaging 25.5 points, 6.6 rebounds and 2.1 blocks. New York is 1-5 in games Porzingis has missed due to injury. In other injury news, Hornacek said Tim Hardaway Jr. has been cleared to jump lightly but still hasn't been cleared to run.
Hardaway Jr. has been sidelined since Dec. 3 with a stress injury in his lower left leg. He will be re-evaluated on Tuesday, meaning he will be sidelined for the Knicks' Christmas Day game against the Philadelphia 76ers.
ESPN's Ian Begley contributed to this report.