The accident happened around 11:00 a.m. on the northbound ramp from Route 130 to Route 90.
Authorities say the tanker truck was carrying nearly 9,000 gallons of fuel that caught fire, spewing thick, black smoke into the sky.
Video shows the truck burning just a few hundred feet from a neighborhood. The smoke could be seen 5 miles away in downtown Philadelphia.
Firefighters began dousing the truck with foam around noon, and it appeared to be out 10 minutes later, but it then reignited. Firefighters had it mostly under control again by 12:20 p.m.
Authorities say the driver managed to get out of the vehicle.
It's not clear what caused the truck to overturn.
Information from The Associated Press was used in the writing of this post.