It is one of 10 vaccination hubs throughout the five boroughs offering the Moderna vaccine.
The Moderna shots at city sites can be given to any child 6 months to 6 years old. It is a two-shot series.
The Pfizer vaccine for kids 6 months to 5 years old can be found at non-city sites. It is a three-shot series for that age group.
Before the doors were open, many parents were at the city's vaccine sites with their little ones in tow, not wanting to wait a minute longer to give their children COVID vaccine protection.
With stuffed animals in hand for comfort, they strolled in one by one, for the day that so many parents have been waiting on.
"She was 5 months old when the pandemic began, so this has been her life," said Max Bookman, a parent.
Now the campaign to convince parents begins.
"This is different, adult vaccines is one thing, children vaccines, parents are going to have a lot of questions," Mayor Eric Adams said.
For instance, what if the parent was vaccinated while pregnant or vaccinated while breastfeeding? Is their child already protected?
"The way that antibodies pass through breast milk is not the same as the way that antibodies build up in the body through vaccination," said Dr. Ashwin Vasan, NYC Health Commissioner.
Health officials are urging parents to ask questions.
"Reach out to your provider, reach out to us, we are here to answer your questions. We are here to break through all the misinformation, the disinformation," Dr. Vasan said.
For many kids who've only lived and can only remember life during a pandemic, this is a chance at normal.
"She's never been to the grocery store," Bookman said. "A completely normal thing of life, she has no idea what it's all about."
"We're going to go home to England for the first time in three years," said Jay Wain, a parent.
Some parents did express frustration with the appointment process.
The city health commissioner said they're booking only for the number of vaccines they have available and asking parents to keep checking back.
If you're interested in the city vaccination centers you can visit the city's vaccine finder online to make an appointment. They also take walk ins depending on availability.
ALSO READ | Experts urge swim lessons, water safety to prevent child drownings
* Get Eyewitness News Delivered
* More New York City news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube