It happened at 12:21 a.m. Thursday as people were leaving a house party on Lincoln Avenue and Hewes Street in Brentwood.
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Video from the scene showed a helicopter circling the area as investigators on the ground searched the area.
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Third Precinct officers responded to multiple 911 calls.
Jesus Ramos-Perez, 28, was transported to a local hospital, where he was pronounced dead. Rancel Montilla, 19, of the Bronx has also died from his injuries.
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Three other men were hospitalized as well, for treatment of unspecified injuries.
Anyone with information about the incident is asked to call the Homicide Squad at 631-852-6392 or call anonymously to Crime Stoppers at 1-800-220-TIPS.
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