Police say the three attacked a 25-year-old man on 3029 Briggs Avenue in the Bedford Park section.
The victim suffered a severed finger and cuts to his arms and legs. He is in critical but stable condition.
The suspects fled the scene in an unknown direction.
The first suspect is a Hispanic man in his 20s; last seen wearing a blue and white jacket, a blue baseball cap and white sneakers.
The second suspect is a Hispanic male in his 20s; last seen wearing a blue jacket, a dark colored baseball cap, white pants and black sneakers.
The third individual is a Hispanic in his 20s, with his hair in a ponytail; last seen wearing a black t-shirt, dark colored pants and white sneakers.
Anyone who has any information is asked to call police.