The fire started just before 5 p.m. at a three-story home located at 920 Summit Ave. on West 162nd and 161st streets in the Highbridge section.
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FDNY officials say there was a fire reported on the top floor. It quickly grew to three alarms.
More than 130 emergency personnel rushed to the scene as flames jumped from the windows of the home.
Using multiple hose lines and a tower ladder, firefighters prevented the fire from spreading to other buildings. It was placed under control just before 9:30 p.m.
Officials say five people, including two firefighters, suffered minor injuries. One civilian refused medical attention and the other five were all taken to Lincoln Hospital.
At least 10 residents have been displaced as a result of the fire.
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The cause is under investigation.
This story will be updated as more information becomes available.
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