The fire tore through all three floors of the Holland Avenue building just after 3:30 a.m. Friday.
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A woman who lives in the building said her grandson woke her up, alerting her to the fire on a mattress in his bedroom.
"I tried to get some water, but when I went up with the water it was too much smoke," she said. "I had to run outside."
Firefighters brought the fire under control in about 30 minutes.
Two residents and two firefighters suffered minor injuries in the fire.
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The building houses some 20 people in three units in the building.
Firefighters put their hose through the window of a car that was parked in front of the hydrant.
The cause of the fire is under investigation.
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