The 2009 Mercedes sedan left the northbound roadway, went through the right-lane guardrail and hit a tree just north of the East 233rd Street exit around 12:20 a.m.
Dayan Hunter, 47, of the Bronx, was identified as the driver, and Dave Hunter, 44, of Yonkers, was his passenger. They were pronounced dead at the scene.
Speed was believed to be a factor, but the cause of the crash remains under investigation.
The parkway was closed in both directions near 233rd Street, but had reopened by 6 a.m.