Officials said the victims were shot while exiting a party at Maestros Caterers on Bronxdale Avenue in the Van Nest section just after 12:30 a.m.
A 16-year-old boy shot in the neck later died. He was identified as 16-year-old Sincear Williams of the Bronx.
A 17-year-old was also shot in the left arm. He was taken to the hospital in stable condition.
A black Honda fled the scene, and police were looking for the person or people who fired the shots.
Detectives were looking into what sparked the large fight.
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