It happened at Bergenline Avenue just before 6:30 a.m. Tuesday.
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The driver hit another car, pushing that vehicle into the express bus lane, where it was hit by an Academy bus.
That driver fled the scene but was later located by Port Authority police when his vehicle became disabled.
Two other vehicles were subsequently struck in the aftermath of the initial crash.
Five people were injured in all. None of the injuries were life threatening.
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The crash closed westbound Route 495, stalling traffic around the Lincoln Tunnel for hours.
NJ Transit rerouted buses to Secaucus because they couldn't get to the Port Authority Bus Terminal.
The bus involved in the crash is operated by Academy Bus Lines, which provides daily service from New Jersey to Manhattan.
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