The fire started at about 2 a.m. in a two-story home in Bushwick Avenue in Central Islip.
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7 occupants inside the home heard their smoke detectors go off and were able to make it out safely.
Firefighters were met with intense flames, and one of them fell when a staircase collapsed. He was pulled out by a fellow firefighter.
The two injured firefighters were taken to Stony Brook University Medical Center.
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One occupant of the home was treated for smoke inhalation. None of the injuries are life-threatening.
The fire is believed to be electrical, and is not considered suspicious.