The accident happened on I-78 westbound in Berkeley Heights.
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The dump truck apparently went through a barrier, and slammed into the car as it was heading in the other direction.
All lanes are shut down on I-78 West at Diamond Hill Road approaching the scene of the crash. One eastbound lane is also closed as state police investigate.
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Traffic through the area was backed up for at least seven miles.
Drivers were advised to seek alternate routes, including Route 28 and Route 22.
The identity of the victim has not yet been released.
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