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State police say the 75-year-old victim was conscious as he was being airlifted to Crozer-Chester Medical Center after the crash.
The incident happened in the southbound lanes of the turnpike at 7:30 a.m. Monday near Mile Marker 6, north of Interchange 1 in Olmans Township.
Video showed a black SUV in a grassy area off the highway with a large hole visible in the driver's side of the windshield.
A medical helicopter and several ambulances were seen on the highway a short distance from the vehicle.
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The driver was flown to an area hospital in critical condition.
Both sides of the turnpike were shut down approaching the crash scene as medics attended to the injured driver and police investigated.
All lanes were back open by 9 a.m.