The incidents happened in the Bronx and in Brooklyn.
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Officials say the Bronx fire started on the second floor at around 10:20 p.m., as flames engulfed an apartment unit.
Video footage shows emergency vehicles lining the street in front of the apartment on Rochambeau Avenue.
Firefighters put out the fire, but found 76-year-old Milton Barnes unconscious inside the apartment. Officials say he has severe fire exposure.
Just a few minutes before, another deadly fire broke out on Rochester Avenue in Brooklyn.
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Firefighters found a 54-year-old woman unconscious inside the home. She was pronounced dead at the hospital.
Investigators believe the fire in the Bronx was possibly sparked by a space heater. The cause of the Brooklyn fire is still under investigation.
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