The victim, 21-year-old Jayde Marks of New City, was driving on Route 304 at Germonds Road around 1 a.m. when her car was struck.
Clarkstown police say the driver of the other vehicle, 22-year-old Michael Mercado, was drunk when he ran a red light at the intersection.
Marks was taken to Nyack Hospital where she was pronounced dead. Mercado, of West Haverstraw, was hospitalized with a non-life-threatening injury.
He is facing multiple charges, including vehicular manslaughter, DWI, and refusal to submit to a breath test.
Route 304 was closed for eight hours for the investigation.
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He's now facing multiple charges.