The 4-alarm blaze broke out at about 2 a.m. at a commercial building on Schnectady Avenue in East Flatbush.
Officials say flames completely engulfed the one-story auto business before part of the roof collapsed.
An interior fire attack of the building was called off when compressed air tanks were located inside.
All firefighters were safely removed from the building and an exterior only attack resumed.
168 firefighers and 39 fire units responded.
No injuries were reported. The cause of the fire is under investigation.
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