Police say they attempted to pull over a vehicle at Madison Avenue and 50th Street shortly after 5 p.m.
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They say the vehicle fled and struck a motorcycle and its two passengers on Second Avenue and East 47th Street.
Those passengers were taken to Bellevue Hospital but are not likely to die.
Not far away, police recovered a gun that the men in the vehicle had thrown.
According to officials, the vehicle continued to travel southbound and struck a parked vehicle.
It eventually stopped on East 44th Street between First and Second Avenue.
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That's where four suspects hopped out of the car and fled.
Police were able to take one man into custody.
They are still looking for the other three suspects.
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