Flames broke out on the second floor of a six-story building at 137 West 141st Street around 8:20 p.m.
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It took firefighters about an hour to get the fire under control.
FDNY officials said 9 civilians were injured.
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Five refused medical attention. The other four were taken to Harlem Hospital.
There's no word yet on their conditions.
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The cause of the fire is unknown at this time.
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