NewsCopter 7 was over the building on 176th Street at around 6:15 a.m.
Officials say the fire started on the first floor of the four-story building, before spreading to the other floors.
Authorities say a 50-year-old woman was pulled from the fire in critical condition. A man in his 30s or 40s was found inside the home and was pronounced dead.
A firefighter was also taken to the hospital with minor injuries.
Fire crews attacked flames from the roof and used a long tower ladder to get it under control by 7:45 a.m.
Firefighters faced heavy clutter conditions in the home while battling flames.
The cause is under investigation
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