The fire broke out inside the multi-family home on 85th Street in Woodhaven at around 5:10 a.m.
One firefighter apparently fell through a flight of stairs while battling the blaze.
The firefighter was taken to the hospital with serious injuries.
Two residents also suffered minor injuries.
The home contains four apartments. An unknown number of residents were left homeless.
The cause of the fire is under investigation.
ALSO READ: 2 suspects wanted after violent robbery in Queens apartment
Violent robbery in Queens caught on camera
----------
* More Queens news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube