It happened around 3:30 p.m. on Woodruff Avenue near Ocean Avenue in the Flatbush section.
The circumstances of the shooting are not yet known, but authorities said the 18-year-old victim was shot multiple times and did not survive.
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The second victim, a 33-year-old man shot in the abdomen, suffered non-life threatening injuries.
The investigation is active and ongoing, and there was a large police presence at the scene.
There is no word on whether any suspects are in custody.
Sources say police are looking for a silver BMW.
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