New Jersey State Police responded to the accident just after 7 p.m. in the southbound local lanes in Aberdeen Township in Monmouth County.
The preliminary investigation revealed that a Nissan Sentra and a Nissan Maxima were both traveling south on the Garden State Parkway local lanes when one car sideswiped the other.
The Sentra ran off the road to the right, impacted a metal post, overturned and struck a tree.
The driver and two passengers of the Sentra were killed.
Their identities have not yet been released.
Both sides of the parkway were briefly closed as police investigated.
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