Officers responded around 10:15 p.m. to an apartment at West 144th Street in Hamilton Heights.
Police say they discovered a 79-year-old woman, identified as Lanilda Nuez, unconscious and unresponsive with multiple stab wounds to the stomach.
She was rushed to Mount Sinai Luke's Hospital, where she was pronounced dead.
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Geraldo Balbuena, 68, who police say is the victim's common law husband, was arrested.
Balbuena was charged with murder and criminal possession of a weapon.
The stabbing has left people who live on the block rattled.
"That's really bad, she probably helped me with parking one time ... we're all like a community here on this block," one resident said.
Police say they recovered two knives at the scene.
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