The shooting was reported in front of 215 West 125th Street just before 3 p.m.
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Police say a 20-year-old man was in a dispute with another man, who opened fire on him.
He was shot twice in the left leg and taken to St Luke's Hospital.
A 48-year -old woman, who preliminarily does not appear involved in the dispute, was shot once in the left leg. She was taken to Harlem Hospital.
Both victims were said to be stable.
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The suspect ran away northbound on Adam Clayton Powell Jr. Boulevard. He was last seen wearing a white hooded sweatshirt and red shirt underneath.
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