The fire broke out in the two-story home around 9:30 a.m. on East 187th Street in the Belmont section. It was under control as of 10:44 a.m.
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Of the two people injured, one man is in serious condition at St. Barnabas Hospital. The other person is expected to survive.
The fire spread to a neighboring home.
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The cause of the fire is not yet known.