The flames broke out around 1:30 p.m. at 114-30 158th Street in Jamaica and quickly spread to two neighboring structures.
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Authorities say it appeared a 40-year-old woman was disabled and unable to escape the fire. She died, despite valiant efforts by firefighters to save her.
A ladder was put against the house reaching the second-floor bathroom, where the woman was pulled unresponsive and in cardiac arrest.
She was rushed to Jamaica Hospital, where she was pronounced dead.
A mother was also forced out a second window with her 5-month-old baby. The woman either tossed the infant to rescuers below or jumped out of the window with the child.
Both were hospitalized but are expected to survive.
The cause of the fire is under investigation.
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