Forty-one-year-old Cindy Stowell's final episode ran Wednesday night.
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She walked away with winnings totaling more than $103,000.
Stowell taped the show in August.
She unfortunately passed away earlier this month, one week before her segments aired.
In a video released by the show, Stowell called her appearance "a line in the sand" in her fight against cancer.
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"I really would like the money that I win to be used to help others, and so this seems like a good opportunity," said Stowell.
When Stowell taped the shows, only host Alex Trebek and a few staffers knew she was ill.
The Cancer Research Institute tweeted its thanks for donating, and inspiring others to do the same.