Susie Rabaca, 36, is due to give birth by December 6 and is in desperate need of a bone marrow transplant to treat her leukemia.
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Within days of her story airing November 22, almost 40,000 people registered for the Be The Match registry.
That was a record-breaking weekend for the registry, officials said.
More information about becoming a potential blood stem cell donor is available here from Be The Match
Inspired by the success, the registry has set a new goal of having another 60,000 people sign up in Rabaca's name before she gives birth.
A bone marrow transplant can be a potentially life-saving procedure for those with leukemia. But for the process to work, the donor needs to be a close match.
There are some 30 million people on the worldwide registry, but a match has not yet been found for Rabaca.
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Rabaca is already a mother of three. Her sister is a 50 percent match, but doctors say it's not good enough to treat her aggressive acute myeloid leukemia.
She needs a 100 percent match, but Rabaca's mixed heritage - Latino and Caucasian - has made finding a donor difficult.
Leukemia patient expecting twins hoping for donor to save her life
The registry is particularly of need for people with mixed ethnic heritage - not just to help Rabaca, but for many other potential recipients without a match.
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Rabaca and her family have been on a mission to sign up as many potential donors as possible, and registry officials say the donations that came in over the weekend were more ethnically diverse than average - another good sign for Rabaca.
Once someone has signed up on the registry, they will receive a testing kit in the mail. After obtaining a cheek swab sample and sending it in, lab processing can take up to two months.
Doctors hope they can find a match and give Rabaca a transplant as quickly as possible after she gives birth.
Rabaca says she has one hope this holiday season: "To find my perfect match, so that way, I can be here for my kids and my two on the way."
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