The shooting happened near the Mirage Gentlemen's Lounge in East Farmingdale just before 4 a.m. Suffolk County police say that is where the dispute started.
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Authorities say the man and woman were near the gentlemen's club when they were shot as they drove away.
They then drove to a Sunoco gas station in Farmingdale, where police were called.
The 33-year-old man, identified as Frank Myers, of Wyandanch, died from his injuries. The 27-year-old woman was transported to Nassau University Medical Center in East Meadow and is expected to survive.
Four other occupants of the vehicle were not injured.
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The suspects then fled the strip club in a Range Rover, with up to four people inside.
Route 109 was closed from Route 110 to Route 24 for the investigation.
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