Lottery officials say the winning ticket was sold at Quick Check on New Brunswick Avenue in Phillipsburg.
MORE: The 10 biggest lottery jackpots and their winners
Friday night's winning numbers were 29, 33, 39, 60, 66 and the Mega Ball was 21.
The winner will take home about $159 million in cash after taxes.
The jackpot had been rolling since it was last won on January 1, when a group of 23 New York co-workers won a $437 million prize.
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