Police responded to the incident shortly before 11 p.m. at 301 West 152nd Street in Hamilton Heights.
The men were stabbed in the chest following a dispute with other men in the apartment, investigators said.
35-year-old Hason Correa of the Bronx was pronounced dead at Harlem Hospital. His 56-year-old father remains hospitalized n stable condition.
A gun was found inside the property.
There have been no arrests and the investigation is ongoing.
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