Jayda Perez, 10, and Destiny Perez, 13, were last seen leaving their home in Parkchester just before 1:30 p.m.
Jayda is described as a Hispanic female who is 4'5" and weighs 70 pounds, and Destiny is described as a Hispanic female who is 5'4" and 100 pounds.
Anyone with information in regards to the missing person is asked to call the NYPD's Crime Stoppers Hotline at 1-800-577-TIPS (8477) or for Spanish, 1-888-57-PISTA (74782).