It happened at about 3:10 p.m. at Route 59 and Old Nyack Turnpike in Nanuet.
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Two of the cars were involved in a fender-bender, and had stopped in the right lane.
Police say a third car traveling in the right lane didn't stop, and struck the first two cars.
Four people inside that third car fled the scene but were later taken into custody a short distance from the scene.
A man with a serious leg injury was taken to Westchester Medical Center and the other three who were injured were taken to Nyack Hospital.
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Eastbound Route 59 at Old Turnpike Way was closed for the accident investigation.
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