It happened after 4 p.m. Monday in the area of New Hempstead Road and Conway Court in Ramapo.
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Police say a 2009 Ford Econoline van carrying 11 people - the driver and 10 passengers, which is contrary to earlier reports, which indicated a total of 10 people in the van - veered off the road and struck a tree.
Several occupants had to be extricated by members of the Hillcrest Fire Company No. 1 and New City Fire Engine Co. No. 1.
Some were taken to Nyack Hospital and the rest to Westchester Medical Center.
Two of the passengers, a 47-year-old man and a 22-year-old man, did not survive.
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The extent of injuries to the other nine victims was not immediately clear.
The Ramapo Police Crash Investigation Unit is working to determine what caused the driver to lose control.
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