Police say the crash happened around 1:30 a.m. on Pelhamdale Avenue at the intersection of the Hutchinson River Parkway Northbound exit ramp.
Authorities say the gray Nissan Altima crashed head on into a brick retaining wall off the exit ramp of the parkway.
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The driver, 37-year-old Troy Carter, of Hempstead, suffered severe injuries and was pronounced dead at the scene.
The front seat passenger, 11-year-old Tiara, was critically injured but is recovering in the hospital.
Twin brothers, 7-year-olds Carmello and Romello, were found in the back seat.
They were rushed with severe injuries to Jacobi Hospital, where Carmello later died.
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The cause of the accident is still under investigation.
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