Authorities say the 35-year-old man was stabbed at Macnish Street, near Elmhurst Avenue, in Elmhurst just after 10 p.m.
He reportedly walked five blocks to Elmhurst Hospital, where he is in very critical condition.
Witnesses say the incident happened near the victim's home.
Police responded to the scene to collect evidence, but no arrests were immediately made.
The motive for the stabbing is not known.
Anyone with information is urged to contact police.