The incident happened Saturday night on Pennsylvania Avenue near Lincoln Park.
Authorities say one man was pronounced dead at the scene, while another died a short time later at a hospital.
The victims were identified Sunday as 26-year-old Niger Farrell, of East Orange, and 20-year-old Darnell Holmes, of Newark.
Two other East Orange men, ages 25 and 28, were wounded in the shooting.
Police say their injuries are not considered life-threatening, but further details were not released.
Further details on the shooting were not disclosed, including what type of weapon may have been used. No arrests have been made.
A motive for the shooting remains under investigation.
(The Associated Press contributed to this report)