The crash happened on I-78 eastbound in Warren just west of Exit 40.
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The NJSP said the trooper's vehicle was heading east when it ran off the road and struck a tree.
Emergency crews had to cut the trooper out of the vehicle. He was then transported by helicopter to the hospital in serious condition. Fortunately, he is expected to survive.
PHOTOS: Crash scene after NJ trooper crashes into tree
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Both eastbound and westbound lanes of I-78 were shut down for the investigation.
It's still not clear what caused the accident.