FDNY officials said firefighters responded to the five-story residential apartment building located at 1316 Morris Avenue around 10:45 a.m. for a fire on the fifth floor.
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They say it quickly escalated to a second alarm, bringing about 25 units and 105 firefighters to the scene.
Five people were injured, including two critically.
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The two victims with critical injuries were taken to Lincoln Hospital.
The fire was placed under control around 11:20 a.m.
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An investigation is underway into the cause of the fire.
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