It happened around 6:30 p.m. Friday along the White Horse Pike near Capitol Avenue in Oaklyn.
Police say two vehicles collided at that location. The impact of the crash caused one vehicle to burst into flames.
Three people had to be extricated from their vehicles.
Five vehicles were involved in all. Two of the car front-ends were mangled.
Police have not said what caused the crash.
One victim died at the scene. A second victim died at Cooper University Hospital.
Three other victims are also taken to Cooper. One is critical and the other two are in serious condition.
Reporter Jeff Chirico spoke with a man who was at a nearby diner when the crash happened.
"I just heard a crash. I just come running down the street, and there were just people running all over the place," said Sal Borreggine of Audubon. "I seen the fire trucks coming down, and it was just craziness."
Our sister station, WPVI, was told the roads, at the time, were not icy, but police have not yet released the cause of this crash.