The fire broke out in a vacant home on Summer Street just before 9 p.m. Wednesday and quickly spread.
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Two EMTs returning from another call noticed the smoke and called in the blaze.
Three houses were heavily damaged, and a fourth structure sustained minor damage.
A Clifton firefighter aiding in battling the blaze suffered a minor injury at the scene.
No residents were injured. The Red Cross is assisting six families.
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The cause of the fire is under investigation.
The vacant building where the fire started was frequented by a squatter living in the basement.
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