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The incident happened around 4:45 a.m. on the border of Northeast Philadelphia and Bucks County in Cornwells Heights.
The ramp from Woodhaven Road eastbound to I-95 southbound was blocked, with the truck flipped on its side.
RAW VIDEO: Tractor-trailer hauling vodka overturns
The truck was carrying boxes of bottles of Tito's Vodka.
Some boxes fell out of the truck and spilled onto the roadway.
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The driver of the truck was taken to the hospital to be checked out.